This is a working overview of LC-MS/MS, written for readers who want more than a one-paragraph summary but less than a textbook.
This page was last updated on 2025-09-19 and is reviewed periodically as new material appears.
Laboratory samples of SR9009 are typically handled as research chemicals rather than pharmaceuticals. Suppliers usually state that the material is for research use only and not for human or veterinary administration. Storage recommendations generally call for a freezer at approximately −20 °C, protection from light, and a desiccated environment. The solid is often described as a white to off-white powder. Solubility is commonly reported in organic solvents such as dimethyl sulfoxide and ethanol, with low solubility in water.
Analytical identification and purity assessment often use high-performance liquid chromatography with ultraviolet detection or mass spectrometry. Liquid chromatography–tandem mass spectrometry is used to detect and quantify SR9009 in biological matrices, including urine and blood, for anti-doping or pharmacokinetic studies. Nuclear magnetic resonance spectroscopy can confirm molecular structure. Stability depends on form and storage: the solid is generally more stable than solutions, and repeated freeze–thaw cycles may degrade samples. Purity is typically reported as a percentage from a certificate of analysis.
SR9009 is a synthetic small molecule studied as an agonist of REV-ERB nuclear receptors. REV-ERB alpha and REV-ERB beta help regulate circadian rhythms and metabolic gene expression. In laboratory research, SR9009 has been used to probe how these receptors affect skeletal muscle, liver, and adipose tissue. The compound was identified in academic drug-discovery work and is often described in scientific literature by its chemical name and research code. It is not an approved medicine, and human clinical data remain limited or absent.
SR9009 binds REV-ERB receptors and alters their repressive activity on target genes. This action can change transcription of genes involved in lipid handling, glucose metabolism, and mitochondrial function. In rodent studies, treated animals have shown changes in muscle oxidative capacity and exercise performance, though effects vary by dose, duration, and model. The precise molecular steps connecting receptor binding to whole-body outcomes are still an active area of investigation. Findings in animals do not automatically translate to humans.
| Property | Value | Notes |
|---|---|---|
| Appearance | White to off-white powder | Common supplier description |
| Solubility | Soluble in DMSO and ethanol | Low solubility in water |
| Typical storage | −20 °C, desiccated, dark | For research samples |
| Analytical method | LC-MS/MS | Used for detection and quantification |
| Regulatory status | Prohibited in sport | WADA metabolic modulator class |
SR9009 is a synthetic small molecule studied as an agonist of the nuclear receptors REV-ERBα and REV-ERBβ. It is not a steroid, peptide, or natural hormone. In scientific literature, it appears under the code SR9009 and in non-scientific contexts as Stenabolic. The compound was identified through chemical screening efforts aimed at targeting circadian clock components. Its status remains investigational, and no regulatory agency has approved it as a human medicine.
REV-ERB proteins help regulate daily cycles in gene expression, including genes tied to lipid and glucose metabolism. SR9009 binds these receptors and alters their activity in cell and animal experiments. Consequences observed in rodents include changes in skeletal muscle oxidative capacity, blood lipid levels, and exercise performance. The precise chain from receptor occupancy to whole-body effects is still an active area of study. Human responses cannot be assumed from rodent data.
SR9009 is a synthetic small molecule studied as an agonist of the nuclear receptors REV-ERBα and REV-ERBβ. It is not an approved medicine and has no established human therapeutic use. The compound appears in scientific literature as a tool for probing circadian and metabolic regulation. Online sellers often label it as a research chemical, sometimes using the nickname Stenabolic. Its chemical identity is distinct from selective androgen receptor modulators, stimulants, and peroxisome proliferator-activated receptor delta agonists. Researchers use it mainly in cell and animal experiments.
At the molecular level, SR9009 binds REV-ERBα and REV-ERBβ and alters their repressive activity on target genes. These nuclear receptors help regulate the circadian clock, lipid synthesis, glucose metabolism, and inflammatory pathways. By changing transcription, the compound can shift the timing or magnitude of downstream metabolic processes in model systems. It does not act through androgen receptors or adenosine receptors, which distinguishes it from several substances sold for athletic performance. Whether the same transcriptional changes occur in humans at tolerable exposures remains an open question because controlled human studies are lacking.
=== CNBC documentary and lawsuit === In December 2010 lawyers from Cold Stone Creamery threatened a lawsuit over some of the contents of a then-upcoming documentary by CNBC. Behind the Counter: The Untold Story of Franchising reported on the failures and successes of franchising. After several edits the program was broadcast on CNBC on March 21, 2011. Brands such as Dunkin' Donuts and Five Guys were highlighted as successful franchise brands. Cold Stone Creamery's executives and corporate lawyers were interviewed. The lawsuit was discussed with former franchisees and the litigation threats with CNBC. An apparently successful Cold Stone franchise was also featured. Another expose was not aired due to threats of litigation and stores that were closed for years appeared on search engines for some unknown reason.
== 3D computer graphics == In 1996, Gibson received a research position at the Centre for Image and Sound Research at Simon Fraser University to study anaglyph images. He exhibited some of these images at the 1995 Currents exhibition in Vancouver and in Victoria, British Columbia. In 1996, he built the world's first completely anaglyphic website. Between 2002 and 2004, he studied 3D lenticular printing for his master's degree. By 2006 he was publicly showing autostereoscopic prints. In 2007 he had a major exhibition of this work at the 3D Center of Art and Photography in Portland, Oregon. In February 2011 he exhibited six large lenticular prints at the Blim Gallery in Vancouver, Canada. These prints paid homage to six renowned religious leaders by revealing the penis of God within them.
== Results == The plebiscite took place on 11 July 1920, when Poland appeared on the verge of defeat in the Polish-Soviet War (see Miracle at the Vistula). The pro-German side was able to organise a very successful propaganda campaign by building on the long campaign of Germanisation; notably, the plebiscite asking the electorate to vote for Poland or East Prussia is said to have masked the pro-German choice under the provincial name of East Prussia. However, the weight of that argument can not have been strong because the voters were aware East Prussia was just a German province, not a sovereign state, as an alternative for Germany. The activity of pro-German organisations and the Allied support for the participation of those who were born in the plebiscite area but did not live there any longer helped the vote toward Germany. In the end, the weight of the evidently-substantial number of pro-German emigration voters can be ignored in the light of the 96% pro-German overall total. Anyway, the plebiscite resulted in a vast majority for East Prussia. Only a small part of the territory affected by the plebiscite was awarded to Poland, and most of it remained in Germany. Poland's supposed disadvantage by the Versailles Treaty stipulation was that it enabled those to return to vote if they were born in the plebiscite areas but no longer living there. Most of them were supposed to have been influenced by German national sentiments. For that reason, German nationalist societies and political parties wanted to assist them by facilitating their travel to the plebiscite area.
Sources: en.wikipedia.org
=== Walter Bennett === Dr. Walter Bennett (voiced by Harry S. Robins) is a Black Mesa scientist. He is seen in Half-Life: Blue Shift. In Blue Shift, Dr. Bennett is seen fixing a battery in Dr. Rosenberg's office, along with Dr. Simmons. The three scientists soon get it fixed with the help of Barney Calhoun, and they start their teleportation out of Black Mesa. The four successfully make it out of the facility, making Dr. Bennett one of the few known survivors of the incident. They open the gates and start their journey to the outside world with an SUV. Dr. Bennett is briefly mentioned in Half-Life: Opposing Force. As Adrian Shephard traverses within Sector E of Black Mesa, he enters a testing laboratory where Xen specimens were being experimented on prior to the Resonance Cascade. He opens up a transmission intended for Dr. Bennett, revealing a hologram of a scientist talking about the results of an experiment conducted on a Barnacle, which was one of the Xen creatures being examined. Following the transmission, Shephard takes a nearby Barnacle specimen that was intended for Dr. Bennett to experiment on before the Resonance Cascade. Dr. Bennett's final fate is unknown.
One such study found that administration of DSIP to humans as an adjunct to isoflurane anaesthesia actually increased the heart rate and reduced the depth of anaesthesia instead of deepening it as expected. Low plasma concentrations of DSIP have been found in patients with Cushing's syndrome. In Alzheimer's patients levels of DSIP have been found to be slightly elevated, though this is unlikely to be causal. A preparation of DSIP, Deltaran, has been used to correct central nervous system function in children after antiblastic therapy. Ten children aged 3–16 years were given a ten-day course of Deltaran and their bioelectric activity recorded. It was found that the chemotherapy-induced impairment in the bioelectrical activity of 9 out of the 10 children was reduced by administration of DSIP. DSIP can act antagonistically on opiate receptors to significantly inhibit the development of opioid and alcohol dependence and is currently being used in clinical trials to treat withdrawal syndrome. In one such trial it was reported that in 97% of opiate-dependent and 87% of alcohol-dependent patients the symptoms were alleviated by DSIP administration. In some studies administration of DSIP has alleviated narcolepsy and normalized disturbed sleeping patterns. Safety and possible side-effects of long-term DSIP use haven't been established in clinical research studies.
== Military career == Wilson served with the Rhodesian African Rifles (RAR) before passing selection for the Rhodesian Special Air Service (SAS) in July 1975. He commanded B Squadron from January 1976–February 1978 and was promoted to become second-in-command of the regiment from March 1978–May 1980. He took command in 1980. Wilson's first decoration for valour was the BCR which was awarded on 07 Oct 1977 while he was still a Captain. His second, the SCR, was awarded on 13 April 1979 with Major Wilson in the 2IC post. Following Rhodesia's reconstitution and recognised independence as Zimbabwe in 1980, Wilson was awarded the Grand Cross of Valour on 30 June 1980 while a Major and second-in-command. He was the second and final person to be awarded the honour after Chris Schulenburg, who received the award while serving with the Selous Scouts. Wilson was awarded Wings on Chest (WOC) on 18 April 1979. During Rhodesia's transition to Zimbabwe, Wilson obtained the rank of major and retired after serving as Officer Commanding SAS from April 1980 to the unit's disbandment in December that year. He delivered the final regimental address at Kabrit Barracks on 13 December 1980, before the final lowering of the colours. An account of the role of the SAS in the Rhodesian Bush War was authored by Wilson and Greg Mills, entitled Who Dares Loses: Assessing Rhodesia's Counter-Insurgency Experience. Wilson was appointed as the President of the C-Squadron Rhodesian Special Air Service Association following the death of General Peter Walls.
Sources: en.wikipedia.org
A variety of esters of nandrolone have been marketed and used medically. The most commonly used esters are nandrolone decanoate and to a lesser extent nandrolone phenylpropionate. Examples of other nandrolone esters that have been marketed and used medically include nandrolone cyclohexylpropionate, nandrolone cypionate, nandrolone hexyloxyphenylpropionate, nandrolone laurate, nandrolone sulfate, and nandrolone undecanoate.
Hypoxia occurs due to the decreased oxygen-binding capacity of methemoglobin, as well as the increased oxygen-binding affinity of other subunits in the same hemoglobin molecule, which prevents them from releasing oxygen at normal tissue oxygen levels.
In September 2016, Inhixa and Thorinane were approved for use in the European Union. Thorinane was withdrawn from the market in October 2019. In March 2017, Enoxaparin BECAT, Laboratorios ROVI (Spain) obtained marketing authorization in twenty six countries in Europe. The product is now available in Europe. In October 2020, Noromby and Noromby HP, were approved for medical use in Canada. In November 2020, Inclunox and Inclunox HP were approved for medical use in Canada. In December 2020, Redesca and Redesca HP were approved for medical use in Canada.
Sources: en.wikipedia.org
Legality depends on the country and the intended use. In many places it is sold as a research chemical, but sports and medicine regulations restrict it.
Detection commonly uses liquid chromatography–tandem mass spectrometry. This method can identify the compound in urine or blood at low concentrations.
Typical guidance is −20 °C, dry, and protected from light. Solutions should be aliquoted and limited freeze–thaw cycles should be used.
SR9009 is a synthetic research compound that acts on REV-ERB nuclear receptors. It is not approved for human use and is sold only as a research chemical. Its effects have been studied mainly in cells and rodents.